What are Osler's nodes?

• A. Painless, flat lesions on the trunk.
• B. Painful, raised lesions found on the hands and feet.
• C. Non-tender nodules on the knees.
• D. Vesicular lesions on the lips.

Answer: (B)

Osler's nodes are painful, raised nodules on the pads of the fingers and toes. They occur in infective endocarditis and are thought to arise from immune complex deposition in the skin, causing a tender vasculitic nodule. This tenderness helps distinguish them from similar signs like Janeway lesions, which are painless hemorrhagic lesions on the palms and soles caused by septic emboli. So the description of painful, raised lesions on the hands and feet fits Osler's nodes.