Common complications of Campylobacter Jejuni infection?

• A. Guillain Barré syndrome
• B. Reactive arthritis
• C. Reactive arthritis, Guillain Barré syndrome
• D. Meningitis

Answer: (C)

Campylobacter jejuni infection is well known for triggering autoimmune reactions that can follow the acute illness. The two most classic post-infectious complications are Guillain-Barré syndrome, a demyelinating peripheral neuropathy that can cause ascending weakness, and reactive arthritis, an inflammatory joint condition that can occur weeks after the GI illness. Guillain-Barré is thought to arise from molecular mimicry, where antibodies against Campylobacter antigens cross-react with nerve components such as gangliosides, leading to nerve damage. Reactive arthritis occurs as part of a broader spondyloarthropathy spectrum and is associated with immune responses after infection, with HLA-B27 sometimes playing a role. Meningitis is not a common complication of Campylobacter infection, though very rare cases can occur in specific circumstances. Therefore, the two most typical complications are Guillain-Barré syndrome and reactive arthritis, making the combined option the best choice.